Browsing by Author "Iyiola OA"

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    Frequency of twinning in Kwara State, North-Central Nigeria
    (2013) Iyiola OA; Oyeyemi FB; Raheem UA; Mark FO
    Background Twin birth prevalence varies widely among the world population. Several factors such as genetic, maternal, socio-economic and environmental have been implicated in its incidence. Although these factors are still the subject of a number of investigations variations do exist in the reported incidence of twinning across the world. There is limited information on the frequency of twinning in Kwara state, North Central Nigeria. Aims This study aims to determine the frequency and prevalence of twinning in Kwara state of the North Central Nigeria. We wish to update the current knowledge on the trend and frequency of twinning in North-Central Nigeria and thereby contributing to the demographic studies in the country. Subjects and methods We carried out an 11-year retrospective study on the incidence of twin births between 1998 and 2008. Data were collected from the University of Ilorin Teaching Hospital, Ilorin (UITH), Omosebi Hospital, Ilorin (OHI) and Erinle General Hospital, Erinle (EGHE) all in Kwara state, North-Central Nigeria. These data were pooled together and analyzed by year and maternal age groups of 15–19, 20–24, 25–29, 30–34, 35–39, 40–44, and 45–49years according to the standard method. Results Frequencies of twin births of 37.60, 35.01, and 35.9 per 1000 deliveries were recorded for UITH, OHI and EGHE respectively. The overall average frequency of 37.4 per 1000 deliveries for the three hospitals was recorded in the study. The maternal age group of 25–29years had the highest occurrence of twin births (35.33%), while the lowest was recorded in the 45–49years age group (1.32%). Conclusion This study shows that there is an increase in twinning rate in the Kwara state when compared with previous reports on this subject matter. This is probably due to an increase in awareness and use of ovulation stimulating drugs or multiple embryo transfers among women.
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    Gene frequencies of ABO and Rh blood groups in Nigeria: A review
    (2017) Anifowoshe AT; Owolodun OA; Akinseye KM; Iyiola OA; Oyeyemi BF
    Background ABO and Rhesus factor (Rh) blood type are germane in human life in genetics and clinical studies. Aim of the study The review was undertaken with the objective to provide data on the ABO and Rh(D) blood group distribution and gene frequency across Nigeria which is vital for blood transfusion and susceptibility to disease. Materials and methods Literature search for ABO/Rh blood distribution in Nigeria was done and allele frequencies of A, B, O, D and d were calculated from the frequency recorded from six geopolitical zones in Nigeria. We reported frequency of ABO and Rhesus blood type from 318,940 and 280,514 individuals respectively. Prevalence were reported as percentage and Hardy-Weinberg equilibrium was tested using Chi square test and p was set at 0.05 unless otherwise stated. Results We reported ABO blood group frequencies in the order O>A>B>AB (52.93%, 22.77%, 20.64% and 3.66%) while prevalence of Rh+ was 94.90% from total population studied. Our reported frequencies did not differ from Hardy-Weinberg equilibrium (goodness-of-fit X2 for ABO=1.74 df=3, p<0.05). Allelic frequencies for A(p), B(q) and O(r) are 0.143, 0.130 and 0.728 respectively. Conclusion The study provides information on the distribution/frequency of ABO/Rh(D) blood group and their corresponding allelic proportion in a large Nigeria study. It also revealed how the Nigerian populations in the North, South, West and East vary with respect to genetic traits. This vital information will be important for population genetics and anthropology studies and may be helpful in planning for future health strategy and blueprint, particularly planning with regards to disease management and blood transfusion medicine.