Browsing by Author "Adebisi AA"

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    Cellgevity® attenuates liver distruption, oxidative stress and inflammation in STZ-diabetic male rats
    (2021) Ogunlabi OO; Adegbesan BO; Ezima EN; Adebisi AA
    The imbalance between reactive oxygen species (ROS) production and the innate antioxidant defence promotes oxidative distress and contributes to tissue dysfunctions which are the hallmark of diabetic complications. Diabetic hepatic injury is less reported, yet it is a target organ damage condition related to diabetes. This study investigated the hepato-protective potentials of Cellgevity® in Streptozotocin (STZ)-diabetic male rats. The rats were assigned into – Control group and diabetes induced groups (DM-untreated, DM-treated 1 and DM-treated 2 groups respectively). Separate treatment of the DM-treated 1 and DM-treated 2 groups with therapeutic doses of Cellgevity® (25 mg/kg and 40 mg/kg BW respectively) was conducted for 30 days, while the control and DM-untreated groups receieved oral distilled water (placebo). The animals were then sacrificed and their sera were evaluated for total antioxidant status and biomarkers of hepatic function. The rats’ liver homogenates were also evaluated for inflammation, nitric oxide, lipid peroxidation and antioxidant enzymes activity. Treatment with Cellgevity® significantly increased the serum total antioxidant status (2 fold) and it reduced the serum ALT, AST, ALP and bilirubin levels compared to untreated diabetes by at least 1.4 fold. Hepatic activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) were significantly increased by over 130%, while liver TNF-α, nitrite and MDA levels were reduced by over 140% compared to the diabetic untreated group. The results present promising evidence for the therapeutic potential of Cellgevity® against diabetes-induced liver dysfunction, which might be through the modulation of ROS and inflammation production respectively.
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    Internal mechanisms as tools for conflict resolution: A case study on Share-Tsaragi, Nigeria
    (2021) Olademo O; Omotoye RW; Ikibe SO; Ibraheem LO; Tijani YO; Abubakre SO; Adebisi AA; Aboyeji AJ; Fahm AO; Adimula RA
    Share and Tsaragi are twin communities in Kwara State, Nigeria, living harmoniously for centuries before a crisis on border issues erupted between them. This study argues that internal mechanisms that originate from the people's philosophy and culture are potent tools to sustain peaceful co-existence between them. The research designs are quantitative and qualitative and data were gathered from participant observations, questionnaires, and interviews. Findings show that government interventions have not been perfectly enforced, hence recurring conflicts. The study concludes that crises are imminent where population growth is without corresponding economic empowerment and socio-cultural integration among the people. Previous research efforts confirm that African conflicts often occur due to the combination of poverty and weak States and institutions. However, data from this research confirm that collaborations and consensus are potent tools to entrench peace in Share and Tsaragi communities.